The Brain Room is a long rectangular room which is predominantly filled with an enormous glass tank of deep green liquid where brains float. This deep green liquid is both stimulating and protective for the brains. All items in this lab are either physically or magically bolted to the floor due to the brain's tendency to throw things around. This means that any Unspeakable that enters this chamber must be alert, both in mind and body, as the brains often like playing with them, either projecting a mental image into their heads or telekinetically throwing any unbolted objects at them.

Work within the Brain Room is split into two divisions: the conscious specialists who study the thoughts of the awakened mind and the sub-conscious specialists who study the involuntary thoughts of the mind.